Ruiying Cheng

PhD Candidate

Department of Biomedical & Nutritional Sciences

University of Massachusetts Lowell

ruiying_cheng@student.uml.edu

BIOGRAPHY AND RESEARCH INTEREST

BIOGRAPHY

Ruiying Cheng is a PhD candidate in the Department of Biomedical and Nutritional Sciences at UMass Lowell. She received a B.S. in Pharmacy from Sichuan University in China and a M.S. in Pharmaceutical Sciences from Northeastern University.

Ruiying’s research interest lies in brain iron overload and associated neurological disorders, including psychiatric mental disorders, and neurodegenerative diseases. She has led research projects exploring phenotypes and biomarkers of several neurodegeneration diseases (e.g. Alzheimer’s Disease, Friedreich’s Ataxia, Aceruloplasminemia) and investigated the therapeutic potential of small molecule metal chelators for the treatment of brain iron overload. Currently, she is researching the therapeutic potential of epigenetic modification in psychotic disorders.

RESEARCH INTERESTS

Psychiatric disorders, ADHD, bipolar disorder, epigenetics, cognitive and behavior disorders, neurodegeneration, Alzheimer’s Disease, Parkinson’s Disease, iron disorders, pharmacokinetics, pharmacodynamics

EDUCATION, HONORS AND PUBLICATION

EDUCATION

M.S., Pharmaceutical Sciences (2020), Northeastern University, Bouve College of Health Sciences, Boston, USA

Certificate in Nanomedicine (2020), Northeastern University, Bouve College of Health Sciences, Boston, USA

B.S., Pharmacy (2018) Sichuan University, West China School of Pharmacy, Chengdu, China

SELECTED AWARDS AND HONORS

ASPET 2023 Travel Award: Deferiprone decreases labile iron in the brain and ameliorates abnormal emotional behavior in mice with brain iron accumulation.
Second Prize Scholarship, 2017
Third Prize Scholarship, 2015

SELECTED PUBLICATIONS

Cheng R, Gadde R, Fan Y, Kulkarni N, Shevale N, Bao K, Choi HS, Betharia S, Kim J. Reversal of genetic brain iron accumulation by N, N'-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice. Arch Toxicol. 2022 Jul;96(7):1951-1962.
Cheng R, Dhorajia VV, Kim J, Kim Y. Mitochondrial iron metabolism and neurodegenerative diseases. Neurotoxicology. 2021 Nov 5;88:88-101.
Ding Ning, Sun Shili, Cheng Ruiying, Zou Huixi, Liao Xin, Mao Shengjun. Comparison and Study on Pharmacokinetics of an alpha-asarone submicron emulsion between intravenous and oral administration. [J] West China Journal of Pharmaceutical Sciences: 2019, 34(01)