Maisha Medha

PhD Candidate

Pharmaceutical Science

Department of Biomedical & Nutritional Sciences

University of Massachusetts Lowell

maisha_medha@student.uml.edu

BIOGRAPHY AND RESEARCH INTEREST

BIOGRAPHY

Maisha Medha is a PhD candidate in the Pharmaceutical Sciences program in the Department of Biomedical and Nutritional Sciences at UMass Lowell. She completed her Bachelors and Masters in Pharmacy from Khulna University, Bangladesh. Maisha's research focuses on the pathophysiology and cellular mechanisms of metal dysregulation and mitochondrial abnormalities in neurodegenerative and movement disorders (Fredreich's ataxia, Wilson's disease, Alzheimer's disease). At present, she is working on evaluating the safety and efficacy of a novel small-molecule in brain-focused toxicity associated with copper overload in Wilson's disease.

RESEARCH INTERESTS

Pharmacokinetics, Pharmacodynamics, Oxidative stress, Mitochondrial abnormalities, Neuroscience, Neurodegenerative disorders, Toxicology

EDUCATION, HONORS AND PUBLICATION

EDUCATION

M. Pharm (2021) Khulna University, Life Science School, Khulna, Bangladesh

B. Pharm (2019) Khulna University, Life Science School, Khulna, Bangladesh

SELECTED AWARDS AND HONORS

Bangladesh National Science and Technology Fellowship Award 2020-21
President’s Gold Medal 2019, Bangladesh
Prime Minister's Gold Medal 2019, Bangladesh

SELECTED PUBLICATIONS

Faruque, M., Medha, M. M., Mahfuz, A. M. U. B., Islam, M. M., & Siraj, M. A. (2025). Deciphering Deleterious nsSNPs in MUC16's SEA Domain: Structural and Functional Implications in Cancer Metastasis via Computational Analysis. Journal of cellular and molecular medicine, 29(11), e70633. doi:10.1111/jcmm.70633
Kim, Y., Jee, E., Baek, H., Medha, M., & Kim, J. (2025). Mitochondrial iron aggregation as a key contributor to Friedreich’s ataxia-associated cardiomyopathy. Physiology. doi:10.1152/physiol.2025.40.S1.1889
Devnath, H. S., Medha, M. M., Islam, M.N., Biswas, P., Debasree, S.O., Hossain, A., Sharmin, R., Islam, M.M., Golder, M., Hasan, N., Biswas, B., Sadhu, S.K. (2025). Bioactive small compounds effectively inhibit ChREBP overexpression to treat NAFLD and T2DM: A computational drug development approach. Heliyon, 11(4), e42477. doi:10.1016/j.heliyon.2025.e42477
Islam, M. T., Medha, M. M., Islam, M.A., Mondal, M., Saha, S., Sarkar, C., Coutinho, H.D.M. (2025). Protective effects of sclareol against paracetamol-induced liver damage in rats, possibly through an oxidative stress-reducing pathway. Pharmacological Research - Natural Products, 6(2025), 100132. doi:10.1016/j.prenap.2024.100132
Devnath, H. S., Biswas, P., Oisay, D.S., Medha, M., Islam, M.N., Biswas, B., Hossain, A., Hasan, M.N. (2025). Bioactive phytocompounds profiling and the evaluation of analgesic, anti-inflammatory, and antihyperglycemic potential of Argyreia capitiformis (Poir.) Ooststr.: A combined in vitro, in vivo, and computational investigations. Journal of Ethnopharmacology,, 337(2025), 118949. doi:10.1016/j.jep.2024.118949
Jee, E., Medha, M., Kim, Y., & Kim, J. (2024). Muscle atrophy is coupled with ferroptosis in the skeletal muscle of Friedreich’s ataxia. Physiology, 39(S1), 1499. doi:10.1152/physiol.2024.39.S1.1499
Islam MA, Medha MM, Nahar AU, Al Fahad MA, Siraj MA, Seidel V. Cancer Protective Role of Selected Dietary Polyphenols via Modulating Keap1/Nrf2/ARE and Interconnected Signaling Pathways. Nutr Cancer. 2023;75(4):1065-1102.
Medha MM, Devnath HS, Biswas B, Bokshi B, Sadhu SK. In silico profiling of analgesic and antihyperglycemic effects of ethanolic leaves extract of Amischotolype mollissima: Evidence from in vivo studies. Saudi J Biol Sci. 20229(7):103312.
Devnath H, Ahmed MI, Medha M, Islam M, Biswas R, Biswas B, et al. HPLC Analysis and Antimicrobial, Antidiarrheal and Antihyperglycemic Properties of Eurya acuminata along with in silico Profiles. Phytomedicine Plus. 2022; 2:100291.