JuOae Chang, PhD

Department of Pharmaceutical Sciences
Northeastern University, Boston, MA

BIOGRAPHY AND RESEARCH INTEREST

BIOGRAPHY

Her research was focused on kinetically explaining iron biology and the conditions that perturb this iron biology. Such conditions could be either genetic modifications or external insults. She also studied the effect of drugs that can possibly restore these perturbations to the normal state. She has always been intrigued by the complexity and beauty of iron biology. This lab has provided her an opportunity to examine it with more depth and focus.

RESEARCH INTERESTS

Toxic metals
Metal chelators
Anemia of inflammation
Iron
Therapeutics
Kinetic modeling

EDUCATION, HONORS AND PUBLICATION

EDUCATION

2013-2019: PhD in Pharmaceutics
Northeastern University, Boston, MA, USA

2008-2012: Bachelor of Biology/Pre-Med
Taylor University, Upland, IN, USA

SELECTED PUBLICATIONS

· Ye Q, Trivedi M, Zhang Y, Böhlke M, Alsulimani H, Chang J, Maher T, Deth R, Kim J. Brain iron loading impairs DNA methylation and alters GABAergic function in mice. FASEB Journal. 2018 Oct 2;201801116RR. doi: 10.1096/fj.201801116RR.

Sukumaran A, Chang J, Han M, Mintri S, Khaw BA, Kim J. Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis. Sci Rep. 2017 Jul 18;7(1):5756. doi: 10.1038/s41598-017-05810-2.

Menon AV, Chang J, Kim J. Mechanisms of divalent metal toxicity in affective disorders. Toxicology. 2016 Jan 2;339:58-72. doi: 10.1016/j.tox.2015.11.001. Epub 2015 Nov 10. Review.

Chang J, Lee CW, Alsulimani HH, Choi JE, Lee JK, Kim A, Park BH, Kim J, Lee H. Role of fatty acid composites in the toxicity of titanium dioxide nanoparticles used in cosmetic products. J Toxicol Sci. 2016;41(4):533-42. doi: 10.2131/jts.41.533.

Han M, Chang J, Kim J. Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity. J Neurochem. 2016 Sep;138(6):918-28. doi: 10.1111/jnc.13717. Epub 2016 Jul 22.

Saputra D, Chang J, Lee BJ, Yoon JH, Kim J, Lee K. Short-term manganese inhalation decreases brain dopamine transporter levels without disrupting motor skills in rats. J Toxicol Sci. 2016;41(3):391-402. doi: 10.2131/jts.41.391.

JuOae Chang, Chojin Kueon, Jonghan Kim. Influence of lead on repetitive behavior and dopamine metabolism in a mouse model of iron overload. Toxicol Res. 2014 Dec; 30(4): 267-76.

Abstracts
Chang J, Alsulimani H, Han M, Ye Q, Buyukozturk F, Kim J. Hands-on Modeling/Simulation Using MATLAB and SimBiology Improves Student Learning in Graduate Pharmacology and Pharmaceutical Sciences Education. Experimental Biology, April 2017, Chicago, IL.

Ye Q, Chang J, Kim J. Brain iron loading impairs manganese metabolism and disrupts GABAergic neurotransmission. Society for Neuroscience, November 2016, San Diego, CA.

Ye Q, Chang J, Han M, Li Y, Alsulimani HH, Menon AV, Deth RC, Kim J. Brain iron loading impairs dopaminergic function and promotes ADHD-like behavior. Society for Neuroscience, October 2015, Chicago, IL.

Chang J, Kueon C, Kim J. Dose-dependent effect of lead (Pb) on repetitive and social behavior in male and female mice. Society of Toxicology, March 2015, San Diego, CA.

Chang J, Kim J. Loss of HFE function impairs brain metal homeostasis and contributes to age-associated memory deficits. RISE Northeastern University, 2015.

Chang J, Surillo M, Kim J. Iron loading decreases behavioral alterations caused by lead (Pb) exposure. RISE Northeastern University, 2015.

Sukumaran A, Chang J, Khaw B-A, Kim J. Cardiac hypertrophy is associated with up-regulation of alpha myosin heavy chain in Hfe-deficient mice. FASEB J 27, 2014.

Chang J, Kim J. Influence of Hfe on neurobehavior in 1-year-old mice. FASEB J 27, 2014.

Saputra D, Chang J, Kim J, Lee K. Effect of three-week exposure of manganese chloride on motor activity and metal homeostasis in rats. Society of Toxicology, March 2014, Phoenix, AZ.

Chang J, Saputra D, Lee K, Kim J. Acute high dose manganese inhalation alters systemic iron metabolism and impairs motor coordination in rats. Society of Toxicology, March 2014, Phoenix, AZ.

Han M, Chang J, Sukumaran A, Alsulimani H, Ye Q, Kim J. Effect of iron supplementation on novel object recognition in growing rats. FASEB J 27:lb285, 2013.

Chang J, Sukumaran A, Kim J. Iron overload hemochromatosis is associated with elevated anxiety in mice. The Toxicologist 132:2693, 2013.