Eunbin Jee, PhD

Postdoctoral Research Associate

Department of Biomedical & Nutritional Sciences

University of Massachusetts Lowell

BIOGRAPHY AND RESEARCH INTEREST

BIOGRAPHY

Dr. Eunbin Jee is a postdoctoral research associate in the Department of Biomedical and Nutritional Sciences at UMass Lowell. Her research focuses on the diseases which induce dysfunction and weakness of skeletal muscle and other organs such as the heart and liver. During her master’s course at Christian-Albrechts University of Kiel in Germany, she participated in a project to improve the function of skeletal muscle in breast cancer patients having chemotherapy-induced peripheral neuropathy. During her Ph.D. at the Nippon Sport Science University in Japan, she researched whether mitochondrial Aldehyde dehydrogenase 2 (alcohol degradation enzyme, which 40% of Asians carry mutation) deficiency alters the function of skeletal muscle during muscle atrophy and hypertrophy. Currently, she is focusing on Friedreich's Ataxia, which is a degenerative genetic disease that induces cardiac and skeletal muscle myopathy. She develops novel therapeutic strategies using chemicals and natural products to decelerate and prevent the progress of the disease.

RESEARCH INTERESTS

Skeletal muscle, Muscle Atrophy, Myopathy, Genetic Diseases, Mitochondria Metabolism, Mitochondria dysfunction, Cancer, Chemotherapy, Aging, Oxidative Stress, Iron Disorders

Dr. Eunbin Jee’s research focuses on the genetic and chronic diseases which induce muscle atrophy. She is also interested in the systematic interaction between skeletal muscle and other organs such as the liver, heart, brain, etc. Using genetically edited animal models, she investigates the characterization and functions of target genes and proteins. Furthermore, she aims to develop novel therapeutics for maintaining healthy muscles and expanding healthy life span for patients and the elderly.

EDUCATION, HONORS AND PUBLICATION

EDUCATION

PhD, Sports Science (2023) Nippon Sport Science University, Tokyo, Japan

Thesis: The effect of aldehyde dehydrogenase 2 deficiency on the adaptation of skeletal muscle

MA, Sports Science (2017) Christian-Albrechts Universität zu Kiel, Kiel, Germany

Thesis: The effect of sensorimotor training on the physical and psychological parameters of breast cancer patients with a chemotherapy induced peripheral neuropathy

BA, Sports Science (2013) Yongin University, Yongin, Korea

SELECTED AWARDS AND HONORS

Rotary Yoneyama Scholarship (2021-2023), Rotary, international humanitarian service organization
Semi-finalist, HIRAKU 3MT competition 2021, 3 minutes research presentation competition, English Division
Otsuka Awards, Sponsor Award of HIRAKU 3MT competition 2021, 3 minutes research presentation competition, English Division

SELECTED PUBLICATIONS

Jee, E., Tamura, Y., Kouzaki, K., Kotani, T. and Nakazato, K*, ALDH2 deficiency enhances denervation-induced muscle atrophy in mouse skeletal muscle. (in preparation)
Jee, E., Tamura, Y., Kouzaki, K., Kotani, T. and Nakazato, K*, ALDH2 deficiency enhances mechanical overload-induced activation of protein synthesis in skeletal muscle. (under review)
Jee, E., Tamura, Y., Kouzaki, K., Kotani, T. and Nakazato, K*, Effect of different types of muscle activity on the gene and protein expression of ALDH family members in C57BL/6J mouse skeletal muscle. Applied Physiology, Nutrition, and Metabolism. (2022)
Kasai, A., Jee, E., Tamura, Y., Kouzaki, K., Kotani, T. and Nakazato, K.*, Acetaldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice. American Journal of Physiology. (2022)
Min, S., Lim, S., Lee, K., Kim, E. and Jee, E.*, The AGTR2 (RS11091046) Gene Polymorphism is Associated with Cycling Performance in Korean Cyclists, Exercise Science, (2022)
Tamura, Y., Jee, E., Kouzaki, K., Kotani, T. and Nakazato, K.*, Effects of endurance training on the expression of host proteins involved in SARS‐CoV‐2 cell entry in C57BL/6J mouse, Physiological Reports, 9(17), p.e15014. (2021)
Min, S., Jee, E., Lee, K., Kim, J. and Lim, S.*, The ACTN3 R577X gth in Korea national combat athletes, Science & Sports, 36(3), pp.236-e1. (2021)
Kim, J., Lim, S., Lee, K., Lee, S., Jee, E., Park, J., Kim, E. and Min, S.*, Comparison of physical fitness levels of artistic swimmers according to adoption of artistic swimmer national team trials physical fitness test, Korean Journal of Sport Science, 30(3), pp.610-619. (2019)